KR-36996 | Urotensin II receptor antagonist | Probechem Biochemicals

Chemical Structure : KR-36996

加入收藏

KR-36996 (KR36996)

货号: PC-28262Not For Human Use, Lab Use Only.

KR-36996 is a potent, selective urotensin II receptor (UTR, U-II receptor, GPR14) antagonist with Ki of 4.44 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

KR-36996 is a potent, selective urotensin II receptor (UTR, U-II receptor, GPR14) antagonist with Ki of 4.44 nM.
KR-36996 significantly inhibits urotensin II-induced stress fiber formation and cellular hypertrophy in H9c2UT cells.
KR-36996 inhibits UII (50 nM) induced proliferation in primary human aortic SMCs (HASMCs) with IC50 of 3.5 nM.
KR-36996 inhibits UII-induced phosphorylation level of ERK1/2, also reduces UII-induced ROS generation
KR-36996 (30 mg/kg, daily oral administration) for 14 days significantly decreased left ventricular weight by 40% (P<0.05) in transverse aortic constriction-induced cardiac hypertrophy model in mice.
KR-36996 decreased interstitial fibrosis and cardiomyocyte hypertrophy in the infarct border zone.

物理化学性质&存储条件

分子量	528.51
分子式	C26H30BrN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)piperidin-4-yl)benzo[b]thiophene-3-carboxamide

参考文献

1. Oh KS, et al. Eur J Pharmacol. 2017 Mar 15;799:94-102.

KR-36996 (KR36996)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

KR-36996 (KR36996)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.