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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-KP-457
KP-457

Chemical Structure : KP-457

CAS No.: 1365803-52-6

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KP-457 (KP457)

货号: PC-25875Not For Human Use, Lab Use Only.

KP-457 is a potent, selective ADAM17 inhibitor with IC50 of 11.1 nM, >50 times more selective for ADAM17 than for other MMPs and ADAM10.

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5 mg ￥1780 In stock
10 mg ￥2880 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KP-457 is a potent, selective ADAM17 inhibitor with IC50 of 11.1 nM, >50 times more selective for ADAM17 than for other MMPs and ADAM10.
KP-457 blocks Zn2+ chelation of the catalytic domain of ADAM17.
KP‐457 blocks GPIbα shedding from iPSC platelets at a lower half‐maximal inhibitory concentration than panmetalloproteinase inhibitor GM‐6001.
KP‐457 exhibits improved GPIbα‐dependent aggregation not inferior to human fresh platelets.
KP-457 effectively enhances the production of functional human iPSC‐derived platelets at 37°C.

物理化学性质&存储条件

分子量 480.55
分子式 C21H24N2O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-((4-(But-2-yn-1-yloxy)phenyl)sulfonyl)-1-(4-(methylsulfonamidomethyl)phenyl)ethyl)-N-hydroxyformamide

参考文献

1. Hirata S, et al. Stem Cells Transl Med. 2017 Mar;6(3):720-730.

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