KN-93 | CaMK II inhibitor | Probechem Biochemicals

Chemical Structure : KN-93

CAS No.: 139298-40-1

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KN-93 (KN93)

货号: PC-24564Not For Human Use, Lab Use Only.

KN-93 is a selective, cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with Ki of 0.37 uM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

KN-93 is a selective, cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with Ki of 0.37 uM.
KN-93 shows no significant effects on the catalytic activity of cAMP-dependent protein kinase, Ca2+/phospholipid dependent protein kinase, myosin light chain kinase and Ca(2+)-phosphodiesterase.
KN-93 also inhibits the autophosphorylation of both the alpha- and beta-subunits of CaMKII。
KN-93 decreases dopamine (DA) levels in PC12h cells, significantly suppressed KCl or acetylcholine-induced tyrosine hydroxylase (TH) phosphorylation.

物理化学性质&存储条件

分子量	501.04
分子式	C26H29ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

参考文献

1. Sumi M, et al. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.

2. Mamiya N, et al. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15.

KN-93 (KN93)

生物&药学活性

物理化学性质&存储条件

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KN-93 (KN93)

生物&药学活性

物理化学性质&存储条件

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