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首页-小分子抑制剂&激动剂-NF-κB Pathway-TAK1-KMU-11361
KMU-11361

Chemical Structure : KMU-11361

CAS No.: 2901875-72-5

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KMU-11361 (KMU11361)

货号: PC-26453Not For Human Use, Lab Use Only.

KMU-11361 is a multi-protein kinase inhibitor which modulates the inflammatory pathways, exerts activity against inflammatory protein kinases (MAPK1, TAK1, IKKα, JAK2, JAK3 etc.).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KMU-11361 is a multi-protein kinase inhibitor which modulates the inflammatory pathways, exerts activity against inflammatory protein kinases (MAPK1, TAK1, IKKα, JAK2, JAK3 etc.).
KMU-11361 suppressed IL-2 protein and mRNA levels in a dose-dependent manner in Jurkat T cells.
KMU-11361 regulates IL-2 production and IKK-NF-κB pathway in activated human Jurkat T cells.
KMU-11361 regulates T cell activity via the TAK1/MAPKs/NF-κB pathway in CD3/CD28-activated Jurkat T cells.
KMU-11361 inhibits the activities of various kinases, including Bmx(h), Flt3(h), IKKα(h), Itk(h), JAK2(h), JAK3(h), Lck(h), MAPK1(h), ROCK-II(h), TAK1(h), Txk(h), TYK2(h), and Yes(h) with inhibition percentage at 1 µM concentration being 91, 97, 93, 78, 82, 98, 86, 86, 94, 77, 86, 96, and 84%, respectively.
KMU-11361 suppresses COX-2, NO, and pro-inflammatory mediator activity in human macrophages and RA-FLS cells.
KMU-11361 promotes osteoblastic bone formation and inhibits osteoclastic bone resorption.

物理化学性质&存储条件

分子量 386.46
分子式 C22H22N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-((1H-imidazol-5-yl)methylene)-5-(6-(cyclohexylamino)pyrazin-2-yl)indolin-2-one

参考文献

1. Baek HS, et al. Inflamm Res. 2026 Mar 17;75(1):55.

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