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首页-小分子抑制剂&激动剂-Others-Other Targets-KL1333
KL1333

Chemical Structure : KL1333

CAS No.: 1800405-30-4

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KL1333 (Napazimone)

货号: PC-24962Not For Human Use, Lab Use Only.

KL1333 (Napazimone) is an orally available, small molecule NAD+ modulator, reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KL1333 (Napazimone) is an orally available, small molecule NAD+ modulator, reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
KL1333 is significantly more active and potent than idebenone and CoQ10.
KL1333 increases the intracellular NAD+/NADH ratio, in C2C12 mouse myoblasts, L6 rat myoblasts, and HepG2 human hepatocarcinoma cells, which could be blocked by the NQO1-specific inhibitor ES936.
KL1333 activates SIRT1 and AMPK in a NQO1-dependent manner, induces PGC-1α activation in C2C12 myoblasts.
KL1333 (1 uM) regulates intracellular ATP, lactate, and ROS levels, increases the NAD+/NADH ratio and activates SIRT1, AMPK, and PGC-1α in MELAS fibroblasts.
KL1333 is an activator of the SIRT1/AMPK/PGC-1α signaling network.

物理化学性质&存储条件

分子量 240.26
分子式 C14H12N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-isopropyl-1H-naphtho[1,2-d]imidazole-4,5-dione

参考文献

1. Seo KS, et al. Front Neurol. 2018 Jul 5;9:552.

2. Lee HS, et al. Biomed Pharmacother. 2020 Jun;126:110068.

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