欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-KKL-1005
KKL-1005

Chemical Structure : KKL-1005

CAS No.: 489397-99-1

加入收藏

KKL-1005 (KKL1005)

货号: PC-25448Not For Human Use, Lab Use Only.

KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt.
KKL-1005 inhibits M. tuberculosis trans-translation in in vitro with IC50 of 37 uM.
KKL-1005 inhibits growth of strain H37Rv by 95.5% when present at 10 µM (3.7 µg/mL). 
KKL-1005 inhibits growth of the attenuated M. tuberculosis strain H37Rv ΔRD1 ΔpanCD with MIC of 4.7 ug/mL.
KKL-1005 binds the N-terminal domain of ribosomal protein bL12, binds with purified M. tuberculosis bL12 with MST Kd of 4 uM.
Overexpression of bL12 suppresses growth inhibition by KKL-1005.

物理化学性质&存储条件

分子量 373.37
分子式 C20H15N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-benzamido-2-phenyl-1,2,4-triazol-3-yl)furan-2-carboxamide

参考文献

1. Varshney A, et al. J Bacteriol. 2025 Sep 3:e0023625.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: