KIRA8 (AMG-18) | IRE1α inhibitor | Probechem Biochemicals

Chemical Structure : KIRA8

CAS No.: 1630086-20-2

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KIRA8 (AMG-18, Kira8)

货号: PC-36004Not For Human Use, Lab Use Only.

KIRA8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

KIRA8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.
KIRA8 demonstrates higher potency than KIRA7 in inhibiting XBP1 splicing in the alveolar epithelial cell line MLE12.
KIRA8 attenuates bleomycin-induced increases in lung weight and hydroxyproline, and decreases mRNA expression of collagen 1A1 and fibronectin in murine model of pulmonary fibrosis.

物理化学性质&存储条件

分子量	601.122
分子式	C31H29ClN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide

参考文献

1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.

2. Morita S, et al. Cell Metab. 2017 Apr 4;25(4):883-897.e8.

KIRA8 (AMG-18, Kira8)

生物&药学活性

物理化学性质&存储条件

参考文献

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KIRA8 (AMG-18, Kira8)

生物&药学活性

物理化学性质&存储条件

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