欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-c-Met (HGFR)-KIN-8741
KIN-8741

Chemical Structure : KIN-8741

CAS No.: 2941104-53-4

加入收藏

KIN-8741 (KIN8741)

货号: PC-24703Not For Human Use, Lab Use Only.

KIN-8741 is a potent, selective type IIb c-Met kinase inhibitor with IC50 of 11 nM for both WT and D1228 N c-Met in cell viability assays utilized engineered Ba/F3-TPR-c-Met-WT and Ba/F3-TPR-c-Met-D1228N.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KIN-8741 is a potent, selective type IIb c-Met kinase inhibitor with IC50 of 11 nM for both WT and D1228 N c-Met in cell viability assays utilized engineered Ba/F3-TPR-c-Met-WT and Ba/F3-TPR-c-Met-D1228N.
KIN-8741 exhibits subnanomolar potency in c-Met kinase assays (0.2 to 0.3 nM), demonstrates excellent selectivity in a full kinase panel of >600 kinases at 100 nM.
KIN-8741 broadly and potently inhibits the proliferation of Ba/F3-TPR-c-Met mutant cells, the D1228X and Y1230X mutations are inhibited in the single digit nanomolar EC50 range (except Y1230C EC50 = 13 nM).
KIN-8741 is the most potent c-Met inhibitor against D1228X/Y1230X mutations, compared with type II inhibitors (cabozantinib, glesatinib and merestinib).
KIN-8741 also potently inhibits back pocket mutations L1195X and F1200X (0.7–51 nM), which show varying degrees of resistance to other type II agents.
KIN-8741 (20-60 mg/kg, BID) displays potent antitumor activity against MET D1228N mutant model, and in MET gene amplification and exon14 deletion NSCLC models.

物理化学性质&存储条件

分子量 511.48
分子式 C26H23F2N3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-{3,5-difluoro-4-[(6-{[(2S)-1-hydroxypropan-2-yl]oxy}-7-methoxyquinolin-4-yl)oxy]phenyl}-4-methoxypyridine-3-carboxamide

参考文献

1. Ouyang XS, et al. J Med Chem. 2025 Jun 3. doi: 10.1021/acs.jmedchem.5c00834.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: