KI-TOX-A3

Chemical Structure : KI-TOX-A3

加入收藏

货号: PC-25107Not For Human Use, Lab Use Only.

KI-TOX-A3 is a specific TOX protein (thymocyte selection-associated high mobility group box) binder (KD=0.92 uM) and potent TOX-KAT7 PPI inhibitor with IC50 of 0.51 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

KI-TOX-A3 is a specific TOX protein (thymocyte selection-associated high mobility group box) binder (KD=0.92 uM) and potent TOX-KAT7 PPI inhibitor with IC50 of 0.51 uM.
KI-TOX-A3 significantly reduced TOX-KAT7 interaction at 5 uM in Molt-4 cells overexpresses TOX protein.
KI-TOX-A3 could potentially destabilize the TOX protein in T-ALL cells, perturbed other potential TOX PPIs including KU70/80 and KAT7, modulates multiple interactions within the TOX interactome.
KI-TOX-A3 demonstrates potent and selective intracellular activity against TOX-dependent cell lines (T-ALL and CTCL cell lines).
KI-TOX-A3 impacts TOX protein levels, which may impact the TOX gene in transcription level with TF positive autoregulation.

物理化学性质&存储条件

分子量	319.32
分子式	C18H13N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-7-hydroxy-4-(5-(hydroxymethyl)furan-2-yl)-5H-indeno[1,2-b]pyridine-3-carbonitrile

参考文献

1. Wu B, et al. bioRxiv [Preprint]. 2025 Jun 18:2025.03.03.641115.

KI-TOX-A3

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

KI-TOX-A3

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.