欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-KI-DX-014
KI-DX-014

Chemical Structure : KI-DX-014

CAS No.: 1309288-83-2

加入收藏

KI-DX-014

货号: PC-25281Not For Human Use, Lab Use Only.

KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity.
KI-DX-014 inhibits DDX21's C-terminal domain interaction with RNA.
KI-DX-014 does not impair the ability of the DDX21 to unwind an RNA duplex, shows no inhibitory activity against U15 binding
KI-DX-014 specifically inhibits the binding of structured RNAs, such as 7SK-SL1 and 7SK-SL4, which interact with the CTD of DDX21.
KI-DX-014 does not inhibit the unwinding activity of DDX21 or its binding to nonstructured RNAs.
KI-DX-014 affects the ability of DDX21 to undergo phase separation in vitro.
KI-DX-014 blocks DDX21-dependnet release of P-TEFb from the 7SK snRNP in vitro and Pol II phosphorylation in vivo.
KI-DX-014 suppresses DDX21-dependent phosphorylation of the Pol II CTD by inhibiting P-TEFb release, leading to developmental defects in zebrafish embryos.
DDX21 is a member of the DEAD-box protein family, capable of binding and remodeling RNA structures and RNA–protein complexes through ATP hydrolysis.

物理化学性质&存储条件

分子量 330.39
分子式 C17H22N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-amino-1-((1-(4-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)methyl)pyrrolidine-3-carboxylic acid

参考文献

1. Aiba T, et al. ACS Chem Biol. 2025 Jul 10. doi: 10.1021/acschembio.5c00302.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: