KF38789 | P-selectin inhibitor | Probechem Biochemicals

Chemical Structure : KF38789

CAS No.: 257292-29-8

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KF38789 (KF-38789)

货号: PC-26102Not For Human Use, Lab Use Only.

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding, inhibits binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with IC50 of 1.97 uM.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding, inhibits binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with IC50 of 1.97 uM.
KF38789 does not affect cell adhesion to both E-selectin-Ig and L-selectin-Ig even by 100 uM.
KF38789 inhibits P-selectin-induced superoxide production from human polymorphonuclear cells.
KF38789 significantly inhibits the TG-induced accumulation of leukocytes in the mouse peritoneal cavity.

物理化学性质&存储条件

分子量	375.44
分子式	C19H21NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one

参考文献

1. Ohta S, et al. Inflamm Res. 2001 Nov;50(11):544-51.

KF38789 (KF-38789)

生物&药学活性

物理化学性质&存储条件

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KF38789 (KF-38789)

生物&药学活性

物理化学性质&存储条件

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