KDOAM-25 citrate | KDM5 inhibitor | Probechem Biochemicals

Chemical Structure : KDOAM-25 citrate

CAS No.: 2448475-08-7

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KDOAM-25 citrate (KDOAM 25)

货号: PC-21988Not For Human Use, Lab Use Only.

KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively.
KDOAM-25 weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases.
KDOAM-25 most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells.
KDOAM-25 increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells.

物理化学性质&存储条件

分子量	499.52
分子式	C21H33N5O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinamide 2-hydroxypropane-1,2,3-tricarboxylate

参考文献

1. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380.

KDOAM-25 citrate (KDOAM 25)

生物&药学活性

物理化学性质&存储条件

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KDOAM-25 citrate (KDOAM 25)

生物&药学活性

物理化学性质&存储条件

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