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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-KDM5-C49
KDM5-C49

Chemical Structure : KDM5-C49

CAS No.: 1596348-16-1

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KDM5-C49 (KDM5 inhibitor C49)

货号: PC-62294Not For Human Use, Lab Use Only.

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.
KDM5-C49 displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.

物理化学性质&存储条件

分子量 308.382
分子式 C15H24N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid

参考文献

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.

2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.

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