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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-KCI838PME
KCI838PME

Chemical Structure : KCI838PME

CAS No.:

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KCI838PME

货号: PC-27015Not For Human Use, Lab Use Only.

KCI838PME is a soluble 3’phosphate monoester prodrug of KCI838, AR-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1, inhibits enzalutamide-resistant patient-derived PCa tumor xenograft.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KCI838PME is a soluble 3’phosphate monoester prodrug of KCI838, AR-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1, inhibits enzalutamide-resistant patient-derived PCa tumor xenograft.

物理化学性质&存储条件

分子量 459.22
分子式 C17H11F3NNa2O6P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium 3-(5-hydroxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-2-yl)phenyl phosphate

参考文献

1. Soave C, et al. bioRxiv [Preprint]. 2026 May 29:2026.05.26.727474.

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