KCI838 | AR-ELK1 inhibitor | Probechem Biochemicals

Chemical Structure : KCI838

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KCI838 (KCI-838)

货号: PC-27014Not For Human Use, Lab Use Only.

KCI838 is a specific small molecule inhibitor of androgen receptor (AR)-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1.

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生物&药学活性

KCI838 is a specific small molecule inhibitor of androgen receptor (AR)-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1.
KCI838 strongly inhibited the BRET signal for binding of AR to ELK1, with 60% and 95% inhibition at 0.4 µM and 10 µM respectively in BRET assays.
KCI838 inhibits AR-dependent cell growth and colony formation in PCa model cells, KCI838 is inactive in AR-negative cell lines.
KCI838 selectively inhibited ELK1-dependent vs. androgen response element (ARE)-driven promoter and gene activation by AR.

物理化学性质&存储条件

分子量	335.28
分子式	C17H12F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-hydroxy-2-(3-hydroxyphenyl)-1-(2,2,2-trifluoroethyl)quinolin-4(1H)-one

参考文献

1. Soave C, et al. bioRxiv [Preprint]. 2026 May 29:2026.05.26.727474.

KCI838 (KCI-838)

生物&药学活性

物理化学性质&存储条件

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KCI838 (KCI-838)

生物&药学活性

物理化学性质&存储条件

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