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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-KBD4466
KBD4466

Chemical Structure : KBD4466

CAS No.: 3023713-87-0

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KBD4466 (KBD-4466)

货号: PC-24869Not For Human Use, Lab Use Only.

KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9.

物理化学性质&存储条件

分子量 468.48
分子式 C24H23F3N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((1S,5R)-1-(5-(1-Methylpiperidin-4-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-8-carbonitrile

参考文献

1. Yuan Y, et al. J Med Chem. 2025 Jul 1. doi: 10.1021/acs.jmedchem.5c00656.

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