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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-KAI407
KAI407

Chemical Structure : KAI407

CAS No.: 1513879-18-9

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KAI407 (KAI-407)

货号: PC-61697Not For Human Use, Lab Use Only.

KAI407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KAI407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages).
    KAI407 prevents blood stage parasitemia in mice (100mg/kg); orally bioavailable.

    物理化学性质&存储条件

    分子量 421.383
    分子式 C22H14F3N5O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide

    参考文献

    1. Zeeman AM, et al. Antimicrob Agents Chemother. 2014;58(3):1586-95.

    2. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.

    3. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

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