K-552 | USP47 inhibitor | Probechem Biochemicals

Chemical Structure : K-552

加入收藏

K-552 (K552)

货号: PC-24507Not For Human Use, Lab Use Only.

K-552 is a specific small molecule inhibitor of USP47 with Kd of 12.3 uM (cUSP47CD), shows more specific interactions with cUSP47CD than hUSP7CD.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

K-552 is a specific small molecule inhibitor of USP47 with Kd of 12.3 uM (cUSP47CD), shows more specific interactions with cUSP47CD than hUSP7CD.
K-552 inhibits lung cancer cell proliferation in a dose-dependent manner, increases ubiquitinated c-Myc protein level, inhibits cell viability was decreased in four types of NSCLC cell lines, characterized by KRASG12S (A549) and KRASG12C (H358, Calu-1, and HCC1171).
K-552 effectively destabilizes c-Myc and inhibits KRASG12C-mutated NSCLC cell proliferation.
K-552 enhances the efficacy of Sotorasib in vitro and in vivo.

物理化学性质&存储条件

分子量	399.54
分子式	C26H29N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(3-(4-(2-methoxyphenyl)piperazine-1-yl)propyl)-9H-carbazole

参考文献

1. Shin H, et al. Pharmacol Res. 2025 Apr 1;215:107722.

K-552 (K552)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

K-552 (K552)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.