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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-Jaceosidin
Jaceosidin

Chemical Structure : Jaceosidin

CAS No.: 18085-97-7

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Jaceosidin (4'-Demethyleupatilin, Jaseocidin)

货号: PC-36080Not For Human Use, Lab Use Only.

Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties, activates Bax and down-regulates Mcl-1 and c-FLIP expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties, activates Bax and down-regulates Mcl-1 and c-FLIP expression.
Jaceosidin promotes angiogenesis via activation of VEGFR2/FAK/PI3K/AKT/NF-κB signaling pathways in endothelial cells.
Jaceosidin shows selective suppression of proliferation (IC50 = 82.1 μM in HSC-3 cells and 97.5 μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle, induces apoptotic cell death and inhibits the Akt pathway in oral cancer cells.

物理化学性质&存储条件

分子量 330.292
分子式 C17H14O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one

参考文献

1. Lee HG, et al. J Ethnopharmacol. 2005 Apr 26;98(3):339-43.

2. Han HY, et al. Evid Based Complement Alternat Med. 2018 May 13;2018:5765047.

3. Allison BJ, et al. Nat Prod Res. 2017 Mar;31(6):707-712.

4. Lee TH, et al. Exp Biol Med (Maywood). 2014 Oct;239(10):1325-34.

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