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首页-小分子抑制剂&激动剂-Others-Other Targets-JZ128
JZ128

Chemical Structure : JZ128

CAS No.: 1604811-02-0

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JZ128 (JZ-128)

货号: PC-26113Not For Human Use, Lab Use Only.

JZ128 is a selective, covalent inhibitor of Protein Kinase N3 (PKN3) with IC50 of 120 nM, targets Cys840 in PKN3, has no activity against CDK7 or CDK12/13.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JZ128 is a selective, covalent inhibitor of Protein Kinase N3 (PKN3) with IC50 of 120 nM, targets Cys840 in PKN3, has no activity against CDK7 or CDK12/13.

物理化学性质&存储条件

分子量 545.65
分子式 C32H31N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-4-(4-(dimethylamino)but-2-enamido)-N-(3-((4-(4-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

参考文献

1. Browne CM, et al. J Am Chem Soc. 2019 Jan 9;141(1):191-203.

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