JX3212 | Kir4.1 Inhibitor | Probechem Biochemicals

Chemical Structure : JX3212

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JX3212 (JX-3212)

货号: PC-26200Not For Human Use, Lab Use Only.

JX3212 is a potent, specific and brain penetrant inhibitor of inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) with IC50 of 0.28 uM (−120 mV) and 0.19 uM (+50 mV).

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生物&药学活性

JX3212 is a potent, specific and brain penetrant inhibitor of inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) with IC50 of 0.28 uM (−120 mV) and 0.19 uM (+50 mV).
JX3212 shows minimal inhibition against Kir channel subtypes (Kir1.1/2.1/2.2/4.2).
JX3212 shows effective antidepressant activity in the novelty‐suppressed feeding test (NSFT) and chronic social defeat stress (CSDS) model.
JX3212 demonstrates superior safety margins compared to both (S)‐ketamine and the conventional antidepressant imipramine in murine behavioral assays.

物理化学性质&存储条件

分子量	403.49
分子式	C23H25N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-(dibenzo[b,d]furan-2-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine

参考文献

1. Sisi Wang, et al. Adv Sci (Weinh). 2026 Feb;13(9):e09506.

JX3212 (JX-3212)

生物&药学活性

物理化学性质&存储条件

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JX3212 (JX-3212)

生物&药学活性

物理化学性质&存储条件

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