JX-078 | LAT1 inhibitor | Probechem Biochemicals

Chemical Structure : JX-078

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JX-078 (JX078)

货号: PC-25184Not For Human Use, Lab Use Only.

JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2.

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生物&药学活性

JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2.
JX-078 induces differential metabolomic changes in human PBMCs upon incubation in blood.
JX-078 induces significantly different metabolomic changes in LAT1-expressing cells.
JX-078 exerts antiproliferative effects in cancer cells independent of LAT1.

物理化学性质&存储条件

分子量	373.45
分子式	C24H23NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-([1,1'-biphenyl]-2-ylmethoxy)-2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

参考文献

1. Yan R, et al. Cell Discov. 2021 Mar 23;7(1):16.

2. Morozova V, et al. Biomed Pharmacother. 2025 Jul 31;190:118402.

JX-078 (JX078)

生物&药学活性

物理化学性质&存储条件

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JX-078 (JX078)

生物&药学活性

物理化学性质&存储条件

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