JWZ-5-13 | CDK7 degrader | Probechem Biochemicals

Chemical Structure : JWZ-5-13

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JWZ-5-13 (CDK7 PROTAC)

货号: PC-22665Not For Human Use, Lab Use Only.

JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner.

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生物&药学活性

JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner.
JWZ-5-13 (5 uM) induces CDK7 degradation across ovarian adenocarcinoma cell line OVCAR3, B-cell lymphoma cell line SUDHL5, and T lymphoblast cell line Molt4, lung adenocarcinoma cell line A549.
JWZ-5-13 induces CDK7 degradation in a UPS-dependent manner.
JWZ-5-13 is a selective CDK7 degrader across CDKs and proteome.
JWZ-5-13 displayed bioavailability in a pharmacokinetic study.

物理化学性质&存储条件

分子量	983.25
分子式	C54H66N10O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-2-(dimethylamino)-1-phenylethyl)-3-(4-(6-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohex-1-yn-1-yl)benzamido)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

参考文献

1. Wenzhi Ji, et al. Eur J Med Chem. 2024 Jun 27:276:116613.

JWZ-5-13 (CDK7 PROTAC)

生物&药学活性

物理化学性质&存储条件

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JWZ-5-13 (CDK7 PROTAC)

生物&药学活性

物理化学性质&存储条件

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