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首页-抗体药物偶连体和PROTACs-PROTAC-JWJ-01-368
JWJ-01-368

Chemical Structure : JWJ-01-368

CAS No.: 3069975-18-1

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JWJ-01-368

货号: PC-25326Not For Human Use, Lab Use Only.

JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation.

物理化学性质&存储条件

分子量 506.99
分子式 C27H27ClN4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-((3-(1-((3-chlorophenethyl)amino)cyclobutyl)phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)piperidine-2,6-dione

参考文献

1. Tran NL, et al. Nat Chem Biol. 2025 Aug 11. doi: 10.1038/s41589-025-01978-1.

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