JWJ-01-306

Chemical Structure : JWJ-01-306

加入收藏

货号: PC-25325Not For Human Use, Lab Use Only.

JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells.
JWJ-01-306 induces otent ZBTB11 degradation and off-target degradation of three related C2H2 ZF transcription factors: ZFP91, ZBTB21 and WIZ, in MIA PaCa-2 cells, but not GSPT1.
JWJ-01-306 promotes formation of the CRBN:molecular glue:ZBTB11 ternary complex.
JWJ-01-306 induces OXPHOS downregulation and reprogramming of mitochondrial metabolism in PDAC cells.
JWJ-01-306 resensitizes KRAS inhibitor-resistant PDAC cells to sotorasib, does not show significantly impaired proliferation alone, counters KRAS inhibitor resistance in multiple types of mutant KRAS-driven PDAC.
JWJ-01-306 reprograms the pancreatic cancer cell transcriptome and proteome to counter the high-OXPHOS drug-resistant state.

物理化学性质&存储条件

分子量	574.99
分子式	C28H26ClF3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-((3-(1-((4-chloro-3-(trifluoromethyl)phenethyl)amino)cyclobutyl)phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)piperidine-2,6-dione

参考文献

1. Tran NL, et al. Nat Chem Biol. 2025 Aug 11. doi: 10.1038/s41589-025-01978-1.

JWJ-01-306

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JWJ-01-306

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.