JW-7-25-1 | MELK inhibitor | Probechem Biochemicals

Chemical Structure : JW-7-25-1

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JW-7-25-1 (MELK inhibitor)

货号: PC-61764Not For Human Use, Lab Use Only.

JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.
JW-7-25-1 exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.

物理化学性质&存储条件

分子量	516.524
分子式	C29H23F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(4-hydroxyphenyl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

参考文献

1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.