JTV-519 hemifumarate (K201) | SERCA inhibitor, RyR2 inhibitor

Chemical Structure : JTV-519 hemifumarate

CAS No.: 1435938-25-2

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JTV-519 hemifumarate (K201, JTV519)

货号: PC-63283Not For Human Use, Lab Use Only.

JTV-519 hemifumarate (K201) is a Ca2+-dependent blocker of SERCA and a ryanodine receptor 2 (RyR2) inhibitor.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JTV-519 hemifumarate (K201) is a Ca2+-dependent blocker of SERCA and a ryanodine receptor 2 (RyR2) inhibitor.
JTV-519 displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle.
JTV-519 may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).

物理化学性质&存储条件

分子量	482.64
分子式	C25H32N2O2S.1/2C4H4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hemifumarate

参考文献

1. Darcy YL, et al. Mol Pharmacol. 2016 Aug;90(2):106-15.

2. Inagaki K, et al. Circulation. 2000 Feb 22;101(7):797-804.

3. Ito K, et al. Br J Pharmacol. 2000 Jun;130(4):767-76.

4. Nakaya H, et al. Br J Pharmacol. 2000 Dec;131(7):1363-72.

JTV-519 hemifumarate (K201, JTV519)

生物&药学活性

物理化学性质&存储条件

参考文献

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JTV-519 hemifumarate (K201, JTV519)

生物&药学活性

物理化学性质&存储条件

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