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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-JTC-801
JTC-801

Chemical Structure : JTC-801

CAS No.: 244218-51-7

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JTC-801 (JTC801)

货号: PC-62626Not For Human Use, Lab Use Only.

JTC-801 is a highly potent, selective, orally active NOP receptor (ORL1) antagonist with Ki of 8.2 nM, shows 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively.

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50 mg ￥1480 In stock
100 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JTC-801 is a highly potent, selective, orally active NOP receptor (ORL1) antagonist with Ki of 8.2 nM, shows 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively.
JTC-801 demonstrates anti-nociceptive effects in acute pain models in vivo.

物理化学性质&存储条件

分子量 447.963
分子式 C26H26ClN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride

参考文献

1. Yamada H, et al. Br J Pharmacol, 2002, 135(2), 323-332.

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