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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-JNc-440
JNc-440

Chemical Structure : JNc-440

CAS No.: 1119503-63-7

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JNc-440 (JNc440)

货号: PC-61767Not For Human Use, Lab Use Only.

JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3.

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5 mg ￥480 In stock
10 mg ￥680 In stock
25 mg ￥1180 In stock
50 mg ￥1880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3.
JNc-440 shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.

物理化学性质&存储条件

分子量 440.503
分子式 C26H24N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(2,2-diphenylacetamido)propyl)-4-oxo-1,4-dihydroquinazoline-2-carboxamide

参考文献

1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725.

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