JNK3 inhibitor 29

Chemical Structure : JNK3 inhibitor 29

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货号: PC-26257Not For Human Use, Lab Use Only.

JNK3 inhibitor 29 is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 5 nM, 15-fold and 75-fold selective over JNK2 and JNK1.

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250 mg		Get quote

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生物&药学活性

JNK3 inhibitor 29 is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 5 nM, 15-fold and 75-fold selective over JNK2 and JNK1.
JNK3 inhibitor 29 has significant inhibitions for the phosphorylation of residue T668 of APP, at a concentration of even as low as 1 nM.
JNK3 inhibitor 29 shows strong inhibition (>80% inhibition at 1 μM) for only JNK3 and JNK2 in a panel of 374 wild-type kinases and had a general kinase hit ratio of only 1.6%.
JNK3 inhibitor 29 has good in vivo DMPK properties, good oral bioavailability, and high brain penetration.

物理化学性质&存储条件

分子量	457.91
分子式	C21H17ClFN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxamide, 4-[5-[(2-chloro-6-fluorophenyl)amino]-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-3-oxetanyl-

参考文献

1. Yangbo Feng, et al. ACS Med Chem Lett. 2021 Sep 21;12(10):1546-1552.