JNK3 inhibitor 14bg

Chemical Structure : JNK3 inhibitor 14bg

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货号: PC-26255Not For Human Use, Lab Use Only.

JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α.

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生物&药学活性

JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α.
14bg (5 uM) suppressed TGF-β1-induced c-Jun phosphorylation and fibrotic markers (PAI-1, Col1α1) while restoring E-cadherin expression without cytotoxicity in podocytes.
14bg (5 uM) exerted robust protective effects against TGF-β1-induced fibrotic responses in podocytes without compromising cell viability.
14bg (2 or 6 mg/kg, i,p.) alleviated renal injury and albuminuria in an Adriamycin-induced nephropathy model.

物理化学性质&存储条件

分子量	559.47
分子式	C24H24Cl2N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-(3,4-Dichlorophenyl)-5-(2-((1-(dimethylcarbamoyl)piperidin-3-yl)amino) pyrimidin-4-yl)imidazo[2,1-b]thiazole-2-carboxamide

参考文献

1. Joonhong Jun, et al. J Med Chem. 2026 Feb 12;69(3):3077-3099.