JNJ-9676 | SARS-CoV-2 M protein inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-9676

加入收藏

JNJ-9676 (JNJ 9676)

货号: PC-24314Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JNJ-9676 is a potent, specific small-molecule inhibitor of SARS-CoV-2 and SARS-CoV, binds to SARS-CoV-2 M protein, reduces SARS-CoV-2 (B1 variant) production of viral RNA with EC50/EC90 of 94/132 nM respectively.
JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and sarbecovirus strains from bat and pangolin zoonotic origin
JNJ-9676 binding induces substantial conformational changes in the M protein dimer, resulting in a novel conformational state.
JNJ-9676 (25 mg per kg BID) is able to reduce the viral RNA load and infectious virus in the lung with 3.5 log10[RNA copies per mg lung] and 4 log10[TCID50 per mg lung], respectively.

物理化学性质&存储条件

分子量	497.51
分子式	C28H21F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-cyanophenyl)-5-(4-(difluoro(phenyl)methyl)phenyl)-6-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxamide

参考文献

1. Van Damme E, et al. Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08651-6.

JNJ-9676 (JNJ 9676)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JNJ-9676 (JNJ 9676)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.