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首页-小分子抑制剂&激动剂-Others-Other Targets-JNJ-9350
JNJ-9350

Chemical Structure : JNJ-9350

CAS No.: 326923-09-5

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JNJ-9350 (JNJ9350)

货号: PC-25675Not For Human Use, Lab Use Only.

JNJ-9350 is a potent, selective Spermine oxidase (SMOX) inhibitor with IC50 of 8 nM for human SMOX (hSMOX), shows remarkable selectivity over hPAOX (>89-fold).

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JNJ-9350 is a potent, selective Spermine oxidase (SMOX) inhibitor with IC50 of 8 nM for human SMOX (hSMOX), shows remarkable selectivity over hPAOX (>89-fold).
JNJ-9350 displays dose-response inhibition of hSMOX cellular activity with an IC50 value of 678 nM in A549 cells.
JNJ-9350 demonstrates stabilization of hSMOX with an IC50 of 2.3 μM in cellular hSMOX engagement assays.

物理化学性质&存储条件

分子量 422.49
分子式 C25H22N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(1H-imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide

参考文献

1. Llaveria J, et al. J Med Chem. 2025 Oct 27. doi: 10.1021/acs.jmedchem.5c01449.

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