JNJ-46356479 | mGlu2 PAM | Probechem Biochemicals

Chemical Structure : JNJ-46356479

CAS No.: 1254979-66-2

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货号: PC-27180Not For Human Use, Lab Use Only.

JNJ-46356479 is a potent and selective, orally bioavailable mGlu2 positive allosteric modulator (PAM) with EC50 of 78 nM and Emax=256%.

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JNJ-46356479 is a potent and selective, orally bioavailable mGlu2 positive allosteric modulator (PAM) with EC50 of 78 nM and Emax=256%.

分子量	451.45
分子式	C22H22F5N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine

1. Cid JM, et al. J Med Chem. 2016 Sep 22;59(18):8495-507.

2. Metcalf CS, et al. Epilepsia. 2018 Mar;59(3):724-735.

3. Martínez-Pinteño A, et al. Biomed Pharmacother. 2023 Feb;158:114079.