JNJ-38877605 | MET inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-38877605

CAS No.: 943540-75-8

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JNJ-38877605 (JNJ38877605, JNJ 38877605)

货号: PC-45841Not For Human Use, Lab Use Only.

JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM.
JNJ-38877605 exhibits >600-fold selectivity (cFMS IC50=2.6 uM, the next potently inhibited kinase) against a panel of 250 diverse tyrosine and serine-threonine kinases.
JNJ-38877605 inhibits Met phosphorylation associated with dose-dependent tumor growth inhibition in tumor xenograft models; orally bioavailable.

物理化学性质&存储条件

分子量	377.3502
分子式	C19H13F2N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Quinoline, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-

参考文献

1. Peter King, et al. DOI: 10.1158/1538-7445.AM10-3628 Published April 2010

2. Lolkema MP, et al. Clin Cancer Res. 2015 May 15;21(10):2297-2304.

3. Galimi F, et al. Clin Cancer Res. 2011 May 15;17(10):3146-56.

JNJ-38877605 (JNJ38877605, JNJ 38877605)

生物&药学活性

物理化学性质&存储条件

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JNJ-38877605 (JNJ38877605, JNJ 38877605)

生物&药学活性

物理化学性质&存储条件

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