JNJ-2408068 (R170591, JNJ 2408068) | RSV fusion inhibitor

Chemical Structure : JNJ-2408068

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JNJ-2408068 (R-170591, R170591, JNJ 2408068, JNJ2408068)

货号: PC-60192Not For Human Use, Lab Use Only.

JNJ-2408068 (R170591, JNJ 2408068) is a potent RSV fusion inhibitor with EC50 of 0.16 nM against some lab strains.

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生物&药学活性

JNJ-2408068 (R170591, JNJ 2408068) is a potent RSV fusion inhibitor with EC50 of 0.16 nM against some lab strains.
JNJ-2408068 (R170591) diplays almost 100,000 times better than that of ribavirin (EC50=15 uM).
JNJ-2408068 (R170591) also inhibits the release of proinflammatory cytokines IL-6, IL-8 and Rantes from RSV-infected A549 cells.

物理化学性质&存储条件

分子量	394.523
分子式	C22H30N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-4-methyl-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol

参考文献

1. Battles MB, et al. Nat Chem Biol. 2016 Feb;12(2):87-93.

2. Andries K, et al. Antiviral Res. 2003 Nov;60(3):209-19.

3. Douglas JL, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6.

JNJ-2408068 (R-170591, R170591, JNJ 2408068, JNJ2408068)

生物&药学活性

物理化学性质&存储条件

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JNJ-2408068 (R-170591, R170591, JNJ 2408068, JNJ2408068)

生物&药学活性

物理化学性质&存储条件

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