JNJ-1250132 | Progesterone receptor antagonist | Probechem Biochemicals

Chemical Structure : JNJ-1250132

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JNJ-1250132 (JNJ1250132, RWJ-66826, RTI-6617-003)

货号: PC-27079Not For Human Use, Lab Use Only.

JNJ-1250132 is a steroidal progesterone receptor modulator and high affinity ligand / antagonist for progesterone receptor (PR), inhibits binding of the receptor to DNA in vitro.

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生物&药学活性

JNJ-1250132 is a steroidal progesterone receptor modulator and high affinity ligand / antagonist for progesterone receptor (PR), inhibits binding of the receptor to DNA in vitro.
JNJ-1250132 shows selectivity profile for other steroid receptors.
JNJ-1250132 inhibits progestin-inducible alkaline phosphatase gene expression in T47D human breast cancer cells, and also inhibits their in vitro proliferation.
JNJ-1250132 inhibits gestation in rats and progesterone-dependent endometrial transformation in rabbits with efficacies comparable to mifepristone.
JNJ-1250132 inhibits binding of the human progesterone receptor to a progesterone response element.

物理化学性质&存储条件

分子量	515.69
分子式	C33H41NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(8S,11R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-11-(4-(piperidin-1-yl)phenyl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

参考文献

1. George F Allan, et al. Steroids. 2006 Jul;71(7):578-84.

JNJ-1250132 (JNJ1250132, RWJ-66826, RTI-6617-003)

生物&药学活性

物理化学性质&存储条件

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JNJ-1250132 (JNJ1250132, RWJ-66826, RTI-6617-003)

生物&药学活性

物理化学性质&存储条件

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