JM-20

Chemical Structure : JM-20

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货号: PC-24358Not For Human Use, Lab Use Only.

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生物&药学活性

JM-20 is a benzodiazepine–dihydropyridine hybrid molecule, preventsPC-12 cell death induced either by glutamate, hydrogen peroxide or KCN-mediated chemical hypoxia, a multi-target neuroprotective agent.
JM-20 protected cerebellar granule neurons from glutamate or glutamate plus pentylenetetrazole-induced damage at very low micromolar concentrations.
JM-20 prevented the Ca2+-induced mitochondrial permeability transition in rat liver mitochondria at low micromolar concentrations.
JM-20 also inhibited the mitochondrial hydrolytic activity of F1F0-ATP synthase and Ca2+ influx.

物理化学性质&存储条件

分子量	404.43
分子式	C22H20N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b] [1,5] benzodiazepine

参考文献

1. Nuñez-Figueredo Y, et al. Neuropharmacology. 2014 Oct;85:517-27.

2. Nuñez-Figueredo Y, et al. Eur J Pharmacol. 2014 Mar 5;726:57-65.

JM-20

生物&药学活性

物理化学性质&存储条件

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JM-20

生物&药学活性

物理化学性质&存储条件

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