JH-VIII-157-02 | ALK G1202R inhibitor | Probechem Biochemicals

Chemical Structure : JH-VIII-157-02

CAS No.: 1639422-97-1

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JH-VIII-157-02 (ALK G1202R inhibitor)

货号: PC-35352Not For Human Use, Lab Use Only.

JH-VIII-157-02 is a potent, orally active, CNS-permeable, second-generation inhibitor of ALK G1202R mutant with IC50 of 2 nM, also shows high potency against a variety of other frequently observed mutants (G1269A, S1206Y, F1174L and C1156Y).

规格	价格	库存
1 mg	￥1480	In stock
5 mg	￥3880	In stock
10 mg	￥5980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

JH-VIII-157-02 is a potent, orally active, CNS-permeable, second-generation inhibitor of ALK G1202R mutant with IC50 of 2 nM, also shows high potency against a variety of other frequently observed mutants (G1269A, S1206Y, F1174L and C1156Y).
JH-VIII-157-02 inhibits EML4-ALKWT with IC50 of 2 nM, demonstrates inhibition of CSNK2A1 <10 uM, IRAK1 (IC50 =14 nM), IRAK4 with (IC50=465 nM), CLK4 (IC50=14 nM), RET (IC50=3 nM), RET V804L (IC50=13 nM).
JH-VIII-157-02 potently inhibits proliferation of NSCLC H3122 cell line with IC50 of 5 nM.

物理化学性质&存储条件

分子量	465.557
分子式	C28H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide

参考文献

1. Hatcher JM, et al. J Med Chem. 2015 Dec 10;58(23):9296-9308.

2. Wang H, et al. Drug Des Devel Ther. 2018 May 9;12:1183-1193.

JH-VIII-157-02 (ALK G1202R inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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JH-VIII-157-02 (ALK G1202R inhibitor)

生物&药学活性

物理化学性质&存储条件

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