JH-LPH-33

Chemical Structure : JH-LPH-33

CAS No.: 2414590-04-6

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货号: PC-25650Not For Human Use, Lab Use Only.

JH-LPH-33 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 26 nM and 46 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 1.6 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

物理化学性质&存储条件

分子量	487.92
分子式	C21H21ClF3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-((4-(3-chloro-5-(trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)indolin-1-yl)ethan-1-one

参考文献

1. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.

JH-LPH-33

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物理化学性质&存储条件

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