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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-JH-LPH-106
JH-LPH-106

Chemical Structure : JH-LPH-106

CAS No.: 3053068-91-7

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JH-LPH-106

货号: PC-25653Not For Human Use, Lab Use Only.

JH-LPH-106 is a highly potent LpxH inhibitor with Ki of 0.02 nM, and IC50 of 0.044 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JH-LPH-106 is a highly potent LpxH inhibitor with Ki of 0.02 nM, and IC50 of 0.044 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

物理化学性质&存储条件

分子量 658.11
分子式 C27H27ClF3N5O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(5-((4-(6-chloro-4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)sulfonyl)indoline-1-carbonyl)phenyl)-N-methylmethanesulfonamide

参考文献

1. Amanda F Ennis, et al. JACS Au. 2024 Nov 11;4(11):4383-4393.

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