JG26

Chemical Structure : JG26

CAS No.: 1464910-32-4

加入收藏

货号: PC-25877Not For Human Use, Lab Use Only.

JG26 is a potent, selective ADAM17 inhibitor with IC50 of IC50 of 1.9 nM, weakly inhibits ADAM-10 and MMP-2 (IC50=150 and 240 nM), does not inhibit MMP-1/9/14.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JG26 is a potent, selective ADAM17 inhibitor with IC50 of IC50 of 1.9 nM, weakly inhibits ADAM-10 and MMP-2 (IC50=150 and 240 nM), does not inhibit MMP-1/9/14.
JG26 shows good inhibitory properties on sALCAM shedding in several in vitro assays.
JG26 potently inhibits ADAM8 with IC50 of 12 nM.
JG26 inhibits both ACE2 receptor shedding and SARS-CoV-2 infection.

物理化学性质&存储条件

分子量	594.28
分子式	C19H22Br2N4O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((4-((3,5-Dibromobenzyl)oxy)phenyl)sulfonamido)-N-hydroxy-5-ureidopentanamide

参考文献

1. Cuffaro D, et al. ACS Med Chem Lett. 2021 Oct 8;12(11):1787-1793.

2. Gentili V, et al. Pharmacol Rep. 2025 Feb;77(1):260-273.

3. Nuti E, et al. J Med Chem. 2013 Oct 24;56(20):8089-103.

JG26

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JG26

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.