JG-C3-98

Chemical Structure : JG-C3-98

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货号: PC-27590Not For Human Use, Lab Use Only.

JG-C3-98 is a selective and effective activator of K2P channels TASK-1 and TASK-3 with EC50 of 13 uM and 34 uM for hTASK-1 and hTASK-3, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JG-C3-98 is a selective and effective activator of K2P channels TASK-1 and TASK-3 with EC50 of 13 uM and 34 uM for hTASK-1 and hTASK-3, respectively.
JG-C3-98 shifts the cold threshold to lower temperatures and reduces the mechanical responses of primary sensory neurons in culture.
JG-C3-98 shifts the thermal threshold of cold thermoreceptor neurons from dorsal root ganglia to lower temperatures.
JG-C3-98 shifts the activation threshold of corneal cold thermoreceptor neurons to lower temperatures.
JG-C3-98 reduces the mechanical sensitivity and AITC-evoked responses in vivo, reduces cold allodynia in a model of neuropathic pain.

物理化学性质&存储条件

分子量	450.55
分子式	C25H26N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (2R,3R,4S,5R)-1-benzyl-5-(5-methylthiophen-2-yl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

参考文献

1. De-la-Torre P, et al. Front Pharmacol. 2026 Jun 9;17:1844406.

JG-C3-98

生物&药学活性

物理化学性质&存储条件

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JG-C3-98

生物&药学活性

物理化学性质&存储条件

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