JG-231 |CAS:1627126-59-3 Probechem Biochemicals

Chemical Structure : JG-231

CAS No.: 1627126-59-3

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JG-231 (JG231)

货号: PC-35390Not For Human Use, Lab Use Only.

JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively.
JG-231 reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip).

物理化学性质&存储条件

分子量	619.45
分子式	C22H18BrCl2N3OS4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((5-bromothiophen-2-yl)methyl)-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride

参考文献

1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583.

JG-231 (JG231)

生物&药学活性

物理化学性质&存储条件

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JG-231 (JG231)

生物&药学活性

物理化学性质&存储条件

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