JBSNF-000088 |CAS:7150-23-4 Probechem Biochemicals

Chemical Structure : JBSNF-000088

CAS No.: 7150-23-4

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JBSNF-000088 (JBSNF000088;6-Methoxynicotinamide)

货号: PC-63249Not For Human Use, Lab Use Only.

JBSNF-000088 (6-Methoxynicotinamide) is a small molecule nicotinamide analog that inhibits Nicotinamide N-methyltransferase (NNMT) with IC50 of 1.8, 2.8 and 5.0 µM for human, monkey and mouse NNMT, respectively.

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100 mg	￥980	In stock
200 mg	￥1480	In stock
500 mg	￥2280	In stock
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生物&药学活性

JBSNF-000088 (6-Methoxynicotinamide) is a small molecule nicotinamide analog that inhibits Nicotinamide N-methyltransferase (NNMT) with IC50 of 1.8, 2.8 and 5.0 µM for human, monkey and mouse NNMT, respectively.
JBSNF-000088 reduces body weight, improves insulin sensitivity and normalizes glucose tolerance in mice with high fat diet (HFD)-induced obesity.
JBSNF-000088 also improves glucose handling in ob/ob and db/db mice albeit to a lesser extent and in the absence of weight loss.

物理化学性质&存储条件

分子量	152.153
分子式	C7H8N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Methoxynicotinamide

参考文献

1. Kannt A, et al. Sci Rep. 2018 Feb 26;8(1):3660.

JBSNF-000088 (JBSNF000088;6-Methoxynicotinamide)

生物&药学活性

物理化学性质&存储条件

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JBSNF-000088 (JBSNF000088;6-Methoxynicotinamide)

生物&药学活性

物理化学性质&存储条件

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