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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-JBI-1044
JBI-1044

Chemical Structure : JBI-1044

CAS No.: 2304852-21-7

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JBI-1044 (JBI1044, JBI 1044)

货号: PC-26981Not For Human Use, Lab Use Only.

JBI-1044 is a potent small molecule peptidylarginine deiminase 4 (PAD4) inhibitor with IC50 of <1 uM, shows activity reported in fibrosis, colitis, and cancer-related models.

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2 mg ￥2780 In stock
5 mg ￥4780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JBI-1044 is a potent small molecule peptidylarginine deiminase 4 (PAD4) inhibitor with IC50 of <1 uM, shows activity reported in fibrosis, colitis, and cancer-related models.

物理化学性质&存储条件

分子量 490.00
分子式 C27H28ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(3-aminopiperidin-1-yl)(2-(7-chloro-1-(cyclopropylmethyl)-1H-indol-2-yl)-3,4-dihydro-5-oxa-1,2a-diazaacenaphthylen-7-yl)methanone

参考文献

1. Patent WO2019058393 A1.

2. Aiken SG, et al. Expert Opin Ther Pat. 2025 Jun;35(6):611-621.

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