JB2019A (JB2019)

Chemical Structure : JB2019A

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货号: PC-27589Not For Human Use, Lab Use Only.

JB2019A (JB2019) is a small molecule activator of PAK1 (P21 Activated Kinase 1) and PAK2 (P21 Activated Kinase 2), binds to a site within the auto-inhibitory domain (AID) of PAK2.

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100 mg		Get quote

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生物&药学活性

JB2019A (JB2019) is a small molecule activator of PAK1 (P21 Activated Kinase 1) and PAK2 (P21 Activated Kinase 2), binds to a site within the auto-inhibitory domain (AID) of PAK2.
JB2019A (JB2019) induces an allosteric conformational change in Pak2, stabilizing its active form.
JB2019A (JB2019) reduces arrhythmia and cardiac remodeling in both acute adrenergic and chronic TAC stress conditions.
JB2019A (JB2019) attenuates TAC-induced cardiac oxidative stress and abnormalities in mitochondrial structure.
JB2019A (JB2019) treatment also reduces oxidative stress, decreasing ROS levels and mitochondrial structural changes.
JB2019A (JB2019) reverses metabolic stress-induced cardiac dysfunction in both HFpEF mice and cardiac organoids.

物理化学性质&存储条件

分子量	373.35
分子式	C12H11N3O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-hydroxy-3-nitro-N-(3-sulfamoylphenyl)benzenesulfonamide

参考文献

1. Xu H, et al. Adv Sci (Weinh). 2026 Aug 3:e76964.

2. Li T, et al. Adv Sci (Weinh). 2025 May;12(17):e2411987.

3. Patent WO2026041859 A1.

JB2019A (JB2019)

生物&药学活性

物理化学性质&存储条件

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JB2019A (JB2019)

生物&药学活性

物理化学性质&存储条件

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