Isolinderalactone

Chemical Structure : Isolinderalactone

CAS No.: 957-66-4

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货号: PC-26289Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Isolinderalactone is a sesquiterpene compound derived from the Lindera aggregata root with significant anti-inflammatory and anti-cancer effects, inhibits TNF-α/STAT3 inflammatory pathways, dose-dependently suppresses IL-1β secretion through inhibiting NLRP3 inflammasome activation with IC50 of 2.88 uM, alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages.
Isolinderalactone selectively blocked ASC oligomer formation and disrupted NLRP3 inflammasome complex assembly.
Isolinderalactone demonstrates to exhibit anticancer effects in A549 human non-small cell lung cancer cells.
Isolinderalactone may cause the cell cycle arrest of A549 cells by induction of p21, and induce apoptosis of A549 human non-small-cell lung carcinoma cells through the Fas/sFasL apoptotic system.

物理化学性质&存储条件

分子量	244.29
分子式	C15H16O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aS,4R,8bR)-4,8-Dimethyl-3-methylene-4-vinyl-3a,4,5,8b-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one

参考文献

1. Shao J, et al. Atherosclerosis. 2026 Jan 26;414:120648.

2. Sun S, et al. Eur J Pharmacol. 2026 Mar 6;1019:178733.

3. Chang WA, et al. Mol Med Rep. 2014 May;9(5):1653-9.