Insulin sensitizer C59

Chemical Structure : Insulin sensitizer C59

CAS No.: 2761446-81-3

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货号: PC-25211Not For Human Use, Lab Use Only.

Insulin sensitizer C59 is a small molecule insulin sensitizer that improve insulin-stimulated GLUT4 translocation through binding to Unc119b.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Insulin sensitizer C59 is a small molecule insulin sensitizer that improve insulin-stimulated GLUT4 translocation through binding to Unc119b.
C59 does not trigger significant GLUT4 translocation in the absence of insulin but increased insulin-stimulated GLUT4 translocation in a concentration-dependent manner.
C59 improves GLUT4 translocation and glucose uptake in DIO mice
C59 treatment resulted in a significantly lowered fasting blood glucose and plasma insulin concentrations in DIO mice.
C59 sensitizes insulin action through interaction with Unc119 and Unc119B.
Unc119b interacts with Rac1 and inhibits its activation by insulin, resulting in reduced GLUT4 translocation.

物理化学性质&存储条件

分子量	325.23
分子式	C16H18Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4,5-Dichloro-2-pyridinyl)tricyclo[3.3.1.13,7]decane-1-carboxamide

参考文献

1. Mittal A, et al. Mol Metab. 2025 Aug 1:102230.

2. Yin TC, et al. Cell Chem Biol. 2023 Aug 17;30(8):933-942.e6.