Inflachromene | HMGB1 inhibitor | Probechem Biochemicals

Chemical Structure : Inflachromene

CAS No.: 908568-01-4

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Inflachromene (ICM)

货号: PC-62259Not For Human Use, Lab Use Only.

Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.

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10 mg	￥4580	In stock
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生物&药学活性

Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.
Inflachromene blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification.
Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo.

物理化学性质&存储条件

分子量	377.4
分子式	C21H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione

参考文献

1. Lee S, et al. Nat Chem Biol. 2014 Dec;10(12):1055-60.

2. Cho W, et al. J Med Chem. 2017 Jan 12;60(1):170-179.

Inflachromene (ICM)

生物&药学活性

物理化学性质&存储条件

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Inflachromene (ICM)

生物&药学活性

物理化学性质&存储条件

参考文献

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